What is the main neurotransmitter involved in pain perception?

Substance P is a neuropeptide that plays a critical role in the transmission of pain signals in the nervous system. It is primarily involved in the modulation of pain perception and is found in areas of the central nervous system where pain processing occurs. When tissue damage occurs, Substance P is released and facilitates the transmission of pain information from peripheral nerves to higher brain centers, where the sensation of pain is ultimately perceived.

This compound acts on specific receptors in the spinal cord and brain, further enhancing the perception of pain and contributing to inflammatory responses. The presence of Substance P is particularly significant in chronic pain conditions and is often a target for therapeutic interventions aimed at managing pain. Understanding its function provides insight into the complex mechanisms of pain and why it is considered the main neurotransmitter in pain perception.