Which of the following is a sign of fluid overload in a patient?

Fluid overload occurs when the body retains more fluid than it can excrete, leading to various clinical signs and symptoms. Peripheral edema, which is the swelling of tissues due to excess fluid in the interstitial spaces, is a common manifestation of fluid overload. It often presents as swelling in the lower extremities, such as the legs and ankles, particularly after prolonged standing or sitting.

Weight gain is another significant indicator of fluid overload, as an increase in body weight can result from the accumulation of excess fluid in the body. Patients may notice sudden weight changes, which often correlate with fluid retention over a short period.

To summarize, the presence of peripheral edema along with weight gain directly points to a patient's struggle with fluid balance, affirming the body's state of overload. This makes the option indicating these signs the correct choice for identifying fluid overload in a patient.